5-Bromo-2-indolecarboxylic acid, with CAS:7254-19-5, is a high-purity heterocyclic compound widely recognized as a critical intermediate in pharmaceutical synthesis and medicinal chemistry. As a professional supplier, we adhere to strict quality control standards throughout the production process, ensuring our product meets the rigorous requirements of global pharmaceutical R&D and fine chemical manufacturing.
Product Name :
5-Bromo-2-indolccarboxylic acidCAS No. :
7254-19-5Application :
Orforglipron intermediates5-Bromo-2-indolecarboxylic acid (5-Bromo-2-indolecarboxylic acid) is a high-purity indole derivative, appearing as a white to pale yellow crystalline powder. As a core backbone in medicinal chemistry, it possesses two key reaction sites (bromine at the 5-position and carboxyl group at the 2-position), making it an ideal precursor for constructing complex heterocyclic compounds. Through rigorous synthetic control and recrystallization processes, we ensure high purity and excellent color stability, serving a wide range of innovative drug development and custom synthesis clients worldwide.
Properties
Appearance: White solid
Melting point: 284-288 °C(lit.)
Boiling point: 467.4±30.0 °C (Predicted)
Density: 1.863±0.06 g/cm³ (estimate)
pKa: 3.51±0.30
Storage temp: Store at RT,sealed and protected from light.
Solubility: Soluble in DMSO, methanol, and alkaline aqueous solutions; sparingly soluble in water and nonpolar solvents.
Specification
| Items | Specifications |
| Appearance | White solid |
| Assay by HPLC | 98.8% |
| Purity | 100.0% (99.9727%) |
Applications
5-Bromoindole-2-carboxylic acid (CAS: 7254-19-5) is a multifunctional organic synthetic intermediate with wide applications in pharmaceutical research and development.
- Pharmaceutical Intermediates:
NMDA Receptor Antagonists: Key raw materials used in the synthesis of drugs for the treatment of stroke and neurodegeneration (such as Gavestinel analogs).
Antiviral and Anticancer Drugs: Their kinase backbones are often used in the development of conjugates and antimicrobial tumor drugs.
- Building Blocks:
Bifunctional Reactions: The bromine atom at the 5-position can undergo Suzuki, Heck, and other coupling reactions to introduce aryl or alkenyl groups; the carboxyl group at the 2-position can undergo amidation, esterification, or decarboxylation reactions to construct diverse molecular libraries.
Biological Probes: Used to synthesize fluorescently or radioactively labeled bioactive probes for receptor binding studies.
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