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5-Bromo-2-indolccarboxylic acid CAS:7254-19-5

5-Bromo-2-indolccarboxylic acid CAS:7254-19-5

5-Bromo-2-indolecarboxylic acid, with CAS:7254-19-5, is a high-purity heterocyclic compound widely recognized as a critical intermediate in pharmaceutical synthesis and medicinal chemistry. As a professional supplier, we adhere to strict quality control standards throughout the production process, ensuring our product meets the rigorous requirements of global pharmaceutical R&D and fine chemical manufacturing.

  • Product Name :

    5-Bromo-2-indolccarboxylic acid
  • CAS No. :

    7254-19-5
  • Application :

    Orforglipron intermediates
  • Description

5-Bromo-2-indolecarboxylic acid (5-Bromo-2-indolecarboxylic acid) is a high-purity indole derivative, appearing as a white to pale yellow crystalline powder. As a core backbone in medicinal chemistry, it possesses two key reaction sites (bromine at the 5-position and carboxyl group at the 2-position), making it an ideal precursor for constructing complex heterocyclic compounds. Through rigorous synthetic control and recrystallization processes, we ensure high purity and excellent color stability, serving a wide range of innovative drug development and custom synthesis clients worldwide.

 

Properties

Appearance​: White solid

Melting point: 284-288 °C(lit.)

Boiling point:  467.4±30.0 °C (Predicted)

Density: 1.863±0.06 g/cm³ (estimate)

pKa: 3.51±0.30

Storage temp: Store at RT,sealed and protected from light.

Solubility: Soluble in DMSO, methanol, and alkaline aqueous solutions; sparingly soluble in water and nonpolar solvents.

 

Specification

Items Specifications
Appearance White solid
Assay by HPLC 98.8%
Purity 100.0% (99.9727%)

 

Applications

5-Bromoindole-2-carboxylic acid (CAS: 7254-19-5) is a multifunctional organic synthetic intermediate with wide applications in pharmaceutical research and development.

 

- Pharmaceutical Intermediates:

NMDA Receptor Antagonists: Key raw materials used in the synthesis of drugs for the treatment of stroke and neurodegeneration (such as Gavestinel analogs).

Antiviral and Anticancer Drugs: Their kinase backbones are often used in the development of conjugates and antimicrobial tumor drugs.

 

- Building Blocks:

Bifunctional Reactions: The bromine atom at the 5-position can undergo Suzuki, Heck, and other coupling reactions to introduce aryl or alkenyl groups; the carboxyl group at the 2-position can undergo amidation, esterification, or decarboxylation reactions to construct diverse molecular libraries.

Biological Probes: Used to synthesize fluorescently or radioactively labeled bioactive probes for receptor binding studies.

 

Package

  • #
  • #

 

Standard Packing:  25kg/cardboard drum (lined with double-layer polyethylene bags)

 

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