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3,5-Difluorobenzyl bromideCAS:141776-91-2

3,5-Difluorobenzyl bromideCAS:141776-91-2

3,5-Difluorobenzyl bromide, with CAS number 141776-91-2, is a high-purity fluorinated benzyl halide widely recognized as a critical alkylating agent in pharmaceutical and agrochemical synthesis. As a professional supplier, we adhere to strict quality control standards throughout the production process, ensuring our product meets the rigorous requirements of global drug discovery and fine chemical manufacturing, with special attention to moisture control and packaging safety.

With comprehensive technical support and global supply capabilities, DUDLEY enables seamless integration of this intermediate into your production workflows, from lab-scale R&D to commercial-scale manufacturing.

 

  • Product Name :

    3,5-Difluorobenzyl bromide
  • CAS No. :

    141776-91-2
  • Application :

    Lenacapavir intermediates
  • Description

3,5-Difluorobenzyl bromide is typically a colorless to pale yellow liquid (it may solidify at low temperatures) and is a highly reactive fluorinated organic intermediate. As a key reagent for introducing the 3,5-difluorobenzyl group, it plays a crucial role in the structural modification of drug molecules, significantly improving their lipophilicity and metabolic stability. We employ advanced bromination processes and strictly control impurity levels to ensure high purity and excellent batch stability, making our product widely used in the custom synthesis of pharmaceuticals and pesticides.

 

Properties

- Physical State:  Colorless liquid

- Density: 1.643 g/mL at 25 °C 

- Boiling Point: 88-89 °C / 15 mmHg

- Refractive index:n20/D 1.522

- Solubility: Soluble in common organic solvents such as ethanol, ether, and benzene 

- Special properties: It is a lachrymator, irritating to the eyes and respiratory tract; it is sensitive to water and easily decomposes in water.

 

 

Specification

Items Specifications
Appearance Colorless liquid
Purity 99.80%min

 

Applications

- Pharmaceutical Industry: Antifungal/antiviral drugs: Used to synthesize azole antifungal drug derivatives with broad-spectrum activity.

Kinetic inhibitors: Used to construct antitumor drugs targeting specific sites. The introduction of a 3,5-difluorobenzene ring is often used to mimic the bioactive conformation and block metabolic sites.

 

- Agrochemical Field: used to synthesize novel fluorinated pyrethroid insecticides or fungicides. The introduction of fluorine atoms can enhance efficacy and environmental stability.

 

Organic Synthesis: As a general benzylating agent, it reacts with amines, alcohols, phenols or thiols to synthesize various 3,5-difluorobenzyl ethers, amines or thioether derivatives.

 

DUDLEY is your trusted partner for high-quality organic intermediates and custom synthesis solutions.

 

 

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