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5-Fluoroindole CAS:399-52-0

5-Fluoroindole CAS:399-52-0

5-Fluoroindole, with CAS number 399-52-0, is a high-purity fluorinated indole derivative widely recognized as a critical intermediate in pharmaceutical and fine chemical synthesis. As a professional supplier, we adhere to strict quality control standards throughout the production process, ensuring our product meets the rigorous requirements of pharmaceutical, agrochemical, and biotechnology industries.

  • Product Name :

    5-Fluoroindole
  • CAS No. :

    399-52-0
  • Application :

    Enlicitide/MK-0616 intermediates
  • Description

Our 5-fluoroindole is a white to off-white crystalline powder, a high-purity fluorinated heterocyclic compound. It plays a crucial role in medicinal chemistry as the core framework for the synthesis of fluorinated tryptamines and other bioactive molecules. Because the introduction of fluorine atoms can significantly improve the metabolic stability and lipid solubility of drug molecules, this product is widely used in new drug development and fine chemical production. We employ optimized purification processes to ensure excellent color and low impurity content, meeting the global demand for high-quality raw materials.

 

Properties

Appearance​: White solid

Melting point: 44-48 °C(lit.)

Boiling point:  120 °C( 1mmHg)

Density: 1.26 g/cm³ (estimate)

Storage temp: 2-8°C

Solubility: Soluble in organic solvents such as methanol, ethanol, and DMSO; slightly soluble in water.

 

 

Specification

Items Specifications
Appearance White solid
Purity 99% min
The single biggest unknown impurity ≤0.5%

 

Applications

5-Fluoroindole (CAS: 399-52-0) is a common precursor for constructing fluorinated indole derivatives and is mainly used in the pharmaceutical and pesticide fields. Key applications include:​

 

  • Pharmaceutical Intermediates: Central Nervous System Drugs: Used for the synthesis of serotonin (5-HT) receptor modulators for the treatment of schizophrenia, depression, and migraines (such as analogues of certain triptans).Metabolic and Anti-tumor Drugs: Used for the development of SGLT2 inhibitors and novel anticancer drugs.

 

  • Biochemical Research):Fluorescent probes: Due to their specific fluorescent properties, they can be used to synthesize bioimaging probes.Tryptophan analogs: Used for the synthesis of fluorotryptophan for studying protein structure and function.

 

  • Agrochemicals: Used to synthesize plant growth regulators and highly effective fungicides.

 

 

Package

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Standard Packing:  25kg per fiber drum (lined with polyethylene bag)

 

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