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2-Iodo-5-fluoroacetophenone CAS: 914225-70-0

2-Iodo-5-fluoroacetophenone CAS: 914225-70-0

2-Iodo-5-fluoroacetophenone (CAS: 914225-70-0) is a high-end halogenated aromatic ketone fine chemical intermediate provided by RELYBO. Containing iodine, fluorine and acetyl active functional groups, this compound has abundant reaction sites and strong chemical activity, serving as an essential raw material for the synthesis of high-grade medicines, pesticides and optoelectronic chemicals. Adopting refined synthesis and purification technology, RELYBO guarantees high purity, stable color difference and excellent batch stability, providing customized packaging and stable bulk supply for global customers.

  • Product Name :

    2-Iodo-5-fluoroacetophenone
  • CAS No. :

    914225-70-0
  • Application :

    Lorlatinib intermediates
  • Description

2-Iodo-5-fluoroacetophenone has a molecular formula of C₈H₆FIO and a molecular weight of 264.04. As an aromatic ketone compound, it is substituted with two halogens (fluorine and iodine) on the benzene ring, and the special electronegativity of halogens significantly improves physical properties and biological activity. It appears as pale yellow crystalline solid at room temperature with excellent chemical modifiability, which is easy to undergo coupling, reduction and substitution reactions. With stable molecular skeleton and high-activity functional groups, it is widely used in the synthesis of complex heterocyclic molecules and acts as an indispensable building block in drug development and fine chemical industry.

 

Properties

- Product Name: 2-Iodo-5-fluoroacetophenone

- CAS Number: 914225-70-0

- Molecular Formula: C₈H₆FIO

- Molecular Weight: 264.04

- Form: Crystalline solid

- Color: Pale yellow to light beige

- Density: 1.875 g/cm³

- Boiling Point: 281.2±25.0 °C

- Flash Point: 123.9±23.2 °C

- Solubility: Insoluble in water, soluble in dichloromethane, ethyl acetate, toluene, methanol and other organic solvents

 

 

Specification

Items Specifications
Appearance Crystalline solid
Purity 99% min
The single biggest unknown impurity ≤0.5%

 

Applications

2-Iodo-5-fluoroacetophenone CAS 914225-70-0  is a key pharmaceutical intermediate mainly used for the industrial synthesis of Lorlatinib, a targeted therapy drug for lung cancer.

 

 

Package

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Standard Packing:  25kg per fiber drum (lined with polyethylene bag)

 

 

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